June 20, 2011
Sphingomyelin (SM) is one of the major phospholipids (components of the plasma membranes of cells) of the lipid microdomains.  These are important regulators in the control of lipid entry into storage form, the lipid droplet.  In this study, researchers looked at an enzyme of this SM that you can see in this figure, SMS2.  Why is this important?  This is why: deficiency in this enzyme prevents HFD-induced fatty acid uptake and lipid droplet formation, which would lead to fatty liver, obesity, and insulin resistance.  We want this enzyme inhibited or downregulated in the body.Therefore, you are potentially looking at the next pharmaceutical target for the treatment of obesity and Type-2 diabetes by regulating the lipid domains on the plasma membranes of cells and subsequently, storage of lipid (fat).
Mitsutake et al J Biol Chem. 2011 Jun 13.

Sphingomyelin (SM) is one of the major phospholipids (components of the plasma membranes of cells) of the lipid microdomains.  These are important regulators in the control of lipid entry into storage form, the lipid droplet.  In this study, researchers looked at an enzyme of this SM that you can see in this figure, SMS2.  Why is this important?  This is why: deficiency in this enzyme prevents HFD-induced fatty acid uptake and lipid droplet formation, which would lead to fatty liver, obesity, and insulin resistance.  We want this enzyme inhibited or downregulated in the body.Therefore, you are potentially looking at the next pharmaceutical target for the treatment of obesity and Type-2 diabetes by regulating the lipid domains on the plasma membranes of cells and subsequently, storage of lipid (fat).

Mitsutake et al J Biol Chem. 2011 Jun 13.

April 30, 2011
The truth.

The truth.

April 27, 2011
Your belly fat could be making you hungrier

Researchers in London, Canada identify new source of appetite stimulant

The extra fat we carry around our middle could be making us hungrier, so we eat more, which in turn leads to even more belly fat. Dr. Kaiping Yang and his colleagues at the Lawson Health Research Institute affiliated with The University of Western Ontario found abdominal fat tissue can produce a hormone that stimulates fat cell production. The researchers hope this discovery will change in the way we think about and treat abdominal obesity.

Click to read more…

April 25, 2011
Increases in sugar consumption from 1955 to the year 2000.

Increases in sugar consumption from 1955 to the year 2000.

April 21, 2011

The human genome is estimated to change approximately 0.3-0.5% every million years.  If we examine the way our ancestors ate 10,000 years ago in the Paleolithic to the Neolithic Periods, it had a change of 0.003% compared to the present.  We are still programmed as a hunter-gatherer and presently this is a detriment for our society.  Note in the first figure the significant decreases in iron and fiber and the increases in sodium.  Also note in the second figure the increases in carbohydrates consumed as the primary energy source.  Even 10,000 years ago, when walking constantly to find food, our ancestors did not eat nearly as much carbohydrates to supply their body with energy.  Perhaps to fight the obesity epidemic we must establish a change back to the “caveman” diet of thousands of years ago.

March 23, 2011
Ever consider supplementing with BCAAs?

Branched-chain amino acids (BCAAs), leucine, isoleucine, and valine are a popular supplement among endurance and strength athletes but do they live up to those wanting to lose weight?  New research from the Journal of Nutrition suggests, yes.  The study consisted of a large sample size of 4,429 men and women and found that BCAA intake and obesity were inversely related, meaning that when BCAAs increase, a persons BMI decreases.

 In conclusion, higher dietary BCAA intake is associated with lower prevalence of overweight status/obesity among apparently healthy middle-aged adults from East Asian and Western countries.

Qin et al J Nutr. 2011 Feb;141(2):249-54. Epub 2010 Dec 15.

March 4, 2011
Resveratrol May Be Useful Tool for Reducing Body Fat

 For her thesis entitled Conjugated Linoleic Acid and Resveratrol: the effect of these functional ingredients on the metabolism of triglycerides and adiposity, nutrition and obesity research team member at the University of the Basque Country (UPV/EHU), Ms Arrate Lasa, studied the fat-reducing effect of CLA and resveratrol.

February 28, 2011
Alarming obesity rates

"It is estimated that by 2015, 2.3 billion adults worldwide will be overweight and 700 million will be obese."  

There is still time to change.

Kristin Eckardt et al. Rev Endocr Metab Disord 19 Feb 2011

January 31, 2011
H.I.T. or prolonged endurance training?

Do you wonder whether you should do high intensity training (H.I.T.) or standard prolonged endurance training for improvements in health and weight loss?  Well a recent study from MSSE can help you decide.

H.I.T. for 12 wk is an effective training stimulus for improvement of cardiorespiratory fitness and glucose tolerance, but in relation to the treatment of hyperlipidemia and obesity, it is less effective than prolonged training. Furthermore and in contrast to strength training, 12 wk of H.I.T. had no impact on muscle mass or indices of skeletal health.

Perform a mix of all three  (H.I.T., prolonged running, and strength training) to receive all of the optimal improvements in health.

 

Nybo et al  MSSE 2010 Oct;42(10):1951-8.

January 14, 2011
Microbes in Our Gut Regulate Genes That Control Obesity and Inflammation